These scientific and medical publications are provided for educational purposes only.

Jun 2023

Phase 2 study of TAVT-119 (amlodipine besylate) gel in patients with chronic anal fissure.

Genovéva Filipcsei, László Ritter, László Hornok, Áron Altorjay, Ferenc Ender, Zoltán Tomcsik, Marie Watissée, Elizabeth Manning Duus // ASCRS Annual Meeting

Jun 2023

A novel abiraterone acetate oral suspension for patients with metastatic prostate cancer: An open-label phase 3 randomized trial.

Imanol Martínez Salas, Kenneth M Kernen, Piotr Piasecki, Joelle Hamilton, Chee Goh, Peter Arkosy, Sarah Needleman, Raffaele Ratta, Mehrnaz Tadayon, Marie Watissée, Elizabeth Manning Duus, Robert Dreicer // ASCO Annual Meeting

Apr 2023

In vitro pharmacological characterization of TAVT-135, a novel chloride ion transporter for pan-genotypic treatment of cystic fibrosis.

Roger Ilagan, Martina Gentzsch, József Maléth, Nancy L. Quinney, Viktória Szabó, Florina Zákány, Orsolya Basa-Dénes, László Molnár, Istvan M. Mandity // ATS Conference

Mar 2023

TAVT-135, a novel chloride ion transporter for the pan-genotypic treatment of cystic fibrosis: electrophysiological and mucus-hydration properties.

Roger Ilagan, Martina Gentzsch, József Maléth, Nancy L. Quinney, Viktória Szabó, Florina Zákány, Orsolya Basa-Dénes, László Molnár, Istvan M. Mandity // ECFS Basic Science Conference

Nov 2022

In vitro evaluation of TAVT-135, an artificial pan-genotypic chloride ion transporter.

Martina Gentzsch, David B. Hill, Jozsef Maléth, Nancy L. Quinney, Kaitlyn R. Rouillard, Susan E. Boyles, Laszlo Molnar, Elizabeth Manning Duus, Andreas Maetzel, Istvan M. Mandity // NACFC Annual Meeting

Dec 2021

Dose finding and food effect studies of a novel abiraterone acetate formulation for oral suspension in comparison to a reference formulation in healthy male subjects.

Tamás Jordán, Orsolya Basa-Dénes, Réka Angi, János Orosz, Zsolt Ötvös, Andrea Ujhelyi, Genovéva Filipcsei, László Molnár, Tamás Solymosi, Hristos Glavinas, Dominic Capone, Nicola Whitfield, John McDermott, Litza McKenzie, Lauren Shurety, Elizabeth Manning Duus // Eur J Drug Metab Pharmacokinet

Dec 2019

Dose Escalation Study to Assess the Pharmacokinetic Parameters of a Nano-amorphous Oral Sirolimus Formulation in Healthy Volunteers

Orsolya Basa-Dénes, Réka Angi, Balázs Kárpáti, Tamás Jordán, Zsolt Ötvös, Nikoletta Erdősi, Andrea Ujhelyi, Betti Ordasi, László Molnár, John McDermott, Chris Roe, Litza McKenzie, Tamás Solymosi, Gábor Heltovics, Hristos Glavinas // Eur J Drug Metabol Pharmacokinet

May 2019

Nano-amorphous oral sirolimus formulation exhibits low inter-individual variability and improved exposure

Orsolya Basa-Dénes, Réka Angi, Balázs Kárpáti, Tamás Jordán, Tamás Solymosi, John McDermott, Chris Roe, Litza McKenzie, Gábor Heltovics and Hristos Glavinas // EUFEPS

Mar 2019

Investigations of the mechanism behind the rapid absorption of nano-amorphous abiraterone acetate

Hristos Glavinas, Orsolya Basa-Dénes, Tamás Solymosi, Zsolt Ötvös, Réka Angi, Andrea Ujhelyi, Tamás Jordán, Gábor Heltovics // EUFEPS

Mar 2019

Investigations of the mechanism behind the rapid absorption of nano-amorphous abiraterone acetate

Orsolya Basa-Dénes, Tamás Solymosi, Zsolt Ötvös, Réka Angi, Andrea Ujhelyi, Tamás Jordán, Gábor Heltovics, Hristos Galvinas // Eur  J Pharm Sci

Jan 2019

Preparation, Pre-clinical and Clinical Evaluation of a Novel Rapidly Absorbed Celecoxib Formulation

Réka Angi, Tamás Solymosi, Nikolett Ersdosi, Tamás Jordán, Balázs Kárpáti, Orsolya Basa-Dénes, John McDermott,Chris Roe, Stuart Mair, Zsolt Ötvös, Hristos Glavinas // AAPS PharmSci Tech

Nov 2018

Solubility Measurements at 296 and 310 K and Physicochemical Characterization of Abiraterone and Abiraterone Acetate

Tamás Solymosi, Ferenc Tóth, János Orosz, Orsolya Basa-Dénes, Réka Angi, Tamás Jordán, Zsolt Ötvös, Hristos Glavinas // J. Chem. Eng. Data

Aug 2018

Nano-amorphous Abiraterone acetate formulation with improved bioavailability and eliminated food effect

Tamás Solymosi, Zsolt Ötvös, Réka Angi, Orsolya Basa-Dénes, Tamás Jordán, Hristos Glavinas // World Conference on Nano Drug Delivery

Jun 2018

Novel formulation of abiraterone acetate with significantly higher bioavailability and eliminated food effect might allow higher abiraterone exposure and better patient outcome

Hristos Glavinas, Tamás Solymosi, Zsolt Ötvös, Réka Angi, Betti Ordasi, Tamás Jordán, László Molnár, John McDermott, Vanessa Zann, Ann Church, Stuart Mair, Genovéva Filipcsei and Gábor Heltovics // ASCO Annual Meeting

May 2018

Improved bioavailability of a novel abiraterone acetate formulation is driven by immediate transfer of the drug from amorphous nanoparticles to bile micelles followed by rapid conversion of the drug to abiraterone in the intestine

Hristos Glavinas, Tamás Solymosi, Réka Angi, Orsolya Basa-Dénes, Tamás Jordán, Zsolt Ötvös, Gábor Heltovics // EUFEPS

Mar 2018

Rapid absorption of nano-amorphous abiraterone acetate is driven by improved dissolution and accelerated conversion of the drug to abiraterone in the intestine

Hristos Glavinas, Tamás Solymosi, Réka Angi, Orsolya Basa-Dénes, Tamás Jordán, Zsolt Ötvös, Gábor Heltovics // PBP World Meeting

Sep 2017

Development of an abiraterone acetate formulation with improved oral bioavailability guided by absorption modeling based on in vitro dissolution and permeability measurements.

Tamás Solymosi, Zsolt Ötvös, Betti Ordasi, Tamás Jordán, Sándor Semsey, László Molnár, Soma Ránky, Genovéva Filipcsei, Gábor Heltovics, Hristos Glavinas // Int J Pharm

Aug 2017

Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates substantial positive food effect

Tamás Solymosi, Zsolt Ötvös, Réka Angi, Betti Ordasi, Tamás Jordán, László Molnár, John McDermott, Vanessa Zann, Ann Churc, Stuart Mair, Genovéva Filipcsei, Gábor Heltovics, Hristos Glavinas // Cancer Chemother Pharmacol

Jun 2016

Scalable continuous flow technology for the development of pharmaceutical nanoformulations

Tamás Solymosi, Réka Angi, Tamás Jordán, Betti Ordasi, Balázs Kárpáti, Zsolt Ötvös, László Molnár, Hristos Glavinas, Genovéva Filipcsei // Conference on Frontiers in Organic Synthesis TechnologyFROST

Aug 2015

Sirolimus formulation with improved pharmacokinetic properties produced by a continuous flow method

Tamás Solymosi, Réka Angi, Orsolya Basa-Dénes, Soma Ránky , Zsolt Ötvös, Hristos Glavinas, Genovéva Filipcsei  and Gábor Heltovics // Eur J Pharm Biopharm

Aug 2014

Novel Continuous flow technology for the development of nanostructured Aprepitant formulation with improved pharmacocinetics properties

Réka Angi, Tamás Solymosi, Zsolt Ötvös, Betti Ordasi, Hristos Glavinas, Genovéva Filipcsei, Gábor Heltovics and Ferenc Darvas // Eur J Pharm Biopharm

Aug 2014

Flow chemistry for nanotechnology

Genovéva Filipcsei, Zsolt Ötvös, Réka Angi and Ferenc Darvas // Flow chemistry, Chapter 6, Vol.2.: Applications, Edited by Ferenc Darvas, Volker Hessel, György Dorman

Mar 2012

Physicochemical and in vitro pharmacokinetic comparison of traditional nanomilled and novel NanoActive drug formulations

Réka Angi, Tamás Solymosi, Zsolt Ötvös, Betti Ordasi, Hristos Glavinas, Genovéva Filipcsei, Gábor Heltovics and Ferenc Darvas // PBP World Meeting